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心衰常引起外源性利钠肽(NP)分泌增多,以及应答反应迟钝。这种效应很可能或至少部分地与磷酸二酯酶(PDE)导致的环磷酸鸟苷(cGMP)减少有关。应用西地那非造成PDE_5的快速抑制,是否可以模拟和/或促进外源性利钠肽(NP)注射后的心肾作用?Forfia PR等人为此进行了一项相关研究,研究者将7只实验犬应用快速起搏诱导心衰,并接受BNP灌注30min(2mg/kg/剂,0.02mg/kg/min),隔天给予西地那非(SIL)
Heart failure often causes exogenous natriuretic peptide (NP) secretion increased, and response unresponsive. This effect is likely or at least partially related to a decrease in cyclic guanosine monophosphate (cGMP) caused by phosphodiesterase (PDE). Is it possible to simulate and / or promote the cardiorespiratory effects of exogenous natriuretic peptide (NP) injection after sildenafil caused rapid inhibition of PDE_5? Forfia PR and others conducted a related study, the researchers will be 7 Only experimental dogs were given rapid pacing-induced heart failure and were given BNP for 30 min (2 mg / kg / dose, 0.02 mg / kg / min) and sildenafil (SIL)