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本文报道应用植物血凝素(PHA)为刺激原的氚化胸腺嘧啶核苷掺入淋巴细胞转化试验(~3H-TdR·LCT)检测90例各型肝炎、13例无症状HBsAg携带者,以及41名正常人的细胞免疫状况,并与形态学淋巴细胞转化试验(LCT)、玫瑰花环形成试验(E·RFC)相比较.结果提示,细胞免疫状态与病情预后关系密切.机体受肝炎病毒感染后,细胞免疫受明显抑制,若能迅速恢复,则病程终止;若抑制非常严重,终将促使患者死亡;若受持续抑制或原来机体细胞免疫功能较差,长期未能恢复正常者,则导致慢性化.在各型肝炎及携带者中,LCT均值无明显差异;E·RFC的结果虽与~3H—TdR·LCT相近,但灵敏性不及后者.本文并讨论了细胞免疫增强剂的可能适应证。
This article reports the application of phytohemagglutinin (PHA) to stimulate the original tritiated thymidine incorporation lymphocyte transformation test (~ 3H-TdR · LCT) detection of 90 cases of hepatitis, 13 cases of asymptomatic HBsAg carriers, and 41 normal subjects, and compared with the morphological lymphocyte transformation test (LCT) and rosette formation test (E RFC) .The results suggest that the cellular immune status is closely related to the prognosis of the disease.The body is infected with hepatitis virus After cellular immunity was significantly inhibited, if the rapid recovery, the course of the termination; if the inhibition is very serious, will eventually lead to death; if sustained inhibition or the original cellular immune function is poor, long-term failure to return to normal, resulting in There was no significant difference in the means of LCT in all types of hepatitis and carriers.E · Although the result of RFC was similar to that of ~ 3H-TdR · LCT, the sensitivity was not as good as that of the latter.We also discussed the possibility of cellular immunity enhancer Indications.