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目的:探讨子宫内膜息肉术后复发与息肉中血管内皮细胞生长因子(VEGF)的表达及血管生成的关系。方法:应用免疫组织化学法检测68例行宫腔镜诊治并取得随访的子宫内膜息肉患者术后石蜡标本VEGF和血小板一内皮细胞私附因子一1(CD31),用全自动图像分析系统检测息肉组织的CD31微血管计数(MVQ),对参数进行综合分析。结果:子宫内膜息肉术后复发与VEGF表达、CD31微血管计数均呈正相关关系(2相关系数分别为0.422,0.446,P<0.05)。结论:子宫内膜息肉VEGF表达、息肉血管生成可能对子宫内膜息肉术后复发有重要作用。
Objective: To investigate the relationship between the recurrence of endometrial polyps and the expression of vascular endothelial growth factor (VEGF) and angiogenesis in polyps. Methods: Immunohistochemistry was used to detect the expression of VEGF and platelet-endothelial cell adhesion factor-1 (CD31) in 68 cases of endometrial polyps treated with hysteroscopy and polyp, Tissue CD31 microvessel count (MVQ), a comprehensive analysis of the parameters. Results: The recurrence of endometrial polyps was positively correlated with VEGF expression and CD31 microvessel count (correlation coefficient of 0.422,0.446, P <0.05 respectively). Conclusion: VEGF expression and polypoid angiogenesis in endometrial polyps may play an important role in the postoperative recurrence of endometrial polyps.