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目的探讨胃癌患者营养状况与肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、干扰素-γ(IFN-γ)的关系。方法运用流式细胞小球微阵列术(CBA)对胃癌术前患者(胃癌组)40例和健康体检者(对照组)30例的TNF-α、IL-6、IFN-γ水平进行检测,结合临床及病理资料,分析上述指标与胃癌患者营养状况的关系。结果与对照组相比,胃癌组和有营养风险的胃癌患者TNF-α、IL-6、IFN-γ表达水平增高,差异均有统计学意义(P<0.05)。基于胃癌患者、有营养风险胃癌患者不同性别、病理类型、临床分期的分析中,TNF-α、IL-6的表达水平差异均无统计学意义(P>0.05),而胃癌患者中TNF-α与IL-6、IFN-γ显著相关,IL-6与IFN-γ显著相关。结论 TNF-α、IL-6、IFN-γ表达水平与胃癌患者营养状况有关,与性别、病理类型、临床分期无关;TNF-α、IL-6、IFN-γ可作为早期诊断胃癌营养不良的参考指标。
Objective To investigate the relationship between nutritional status and tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interferon-γ (IFN-γ) in patients with gastric cancer. Methods The levels of TNF-α, IL-6 and IFN-γ in 40 preoperative gastric cancer patients and 30 healthy volunteers (control group) were detected by flow cytometry (CBA) Combined with clinical and pathological data, analysis of the above indicators and nutritional status of patients with gastric cancer. Results Compared with the control group, the expression of TNF-α, IL-6 and IFN-γ in gastric cancer group and those at nutrition risk increased significantly (P <0.05). There was no significant difference in the expression levels of TNF-α and IL-6 between patients with gastric cancer and those with nutritional risk (P> 0.05), while the levels of TNF-α Significantly correlated with IL-6, IFN-γ, IL-6 and IFN-γ significantly correlated. Conclusion The expression of TNF-α, IL-6 and IFN-γ is related to the nutritional status of gastric cancer patients, but not to the sex, pathological type and clinical stage. TNF-α, IL-6 and IFN-γ can be used as early diagnosis of gastric dystrophy reference indicator.