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目的观察甘草酸二铵肠溶胶囊在核苷类抗病毒药物抗病毒治疗慢性乙型肝炎中的早期应用价值。方法 122例慢性乙型肝炎患者随机分为两组,治疗组62例采用恩替卡韦联合甘草酸二铵肠溶胶囊口服,对照组60例仅用恩替卡韦口服,疗程3个月。比较两组疗效。结果治疗组12周时血清丙氨酸氨基转移酶(ALT)复常率明显高于对照组(P<0.01),治疗12周后,治疗组HBVDNA和HBe Ag阴转率与对照组比,差异无统计学意义(P>0.05)。结论甘草酸二铵肠溶胶囊联合恩替卡韦等核苷类药物治疗慢性乙型肝炎能迅速改善肝功能,减轻患者肝功减退导致症状。
Objective To observe the early application value of diammonium glycyrrhizinate enteric-coated capsules in the treatment of chronic hepatitis B with nucleoside antiviral antiviral drugs. Methods One hundred and twenty-two patients with chronic hepatitis B were randomly divided into two groups. Twenty-two patients in the treatment group were treated with entecavir and diammonium glycyrrhizinate enteric-coated capsules orally. The control group, 60 patients were treated with entecavir orally for 3 months. Compare the two groups curative effect. Results After 12 weeks of treatment, the normalization rate of serum alanine aminotransferase (ALT) in the treatment group was significantly higher than that in the control group (P <0.01). After 12 weeks of treatment, the negative rates of HBVDNA and HBeAg in the treatment group were significantly lower than those in the control group No statistical significance (P> 0.05). Conclusion Glycyrrhizic acid diammonium enteric-coated capsules combined with nucleoside drugs such as entecavir for the treatment of chronic hepatitis B can rapidly improve liver function and alleviate the symptoms of liver dysfunction in patients.