本文介绍一种测定乳酸环丙沙星含量的有效方法。在pH =4 0的HAc NaAc缓冲溶液中 ,乳酸环丙沙星可与四苯硼钠定量地形成分子比为 1:1的沉淀 ,待沉淀反应完全后 ,过滤 ,弃去初滤液。以溴酚蓝为指示剂 ,用十六烷基三甲基溴化铵标准溶液滴定续滤液中过量的四苯硼钠 ,方法简便 快速 ,应用于多批乳酸环丙沙星原料药样品的测定 ,其回收率为99 6 6 % - 10 0 2 % ,相对误差 <± 0 40 % ,与中国药典法测得的结果基本一致 This article describes an effective method for the determination of ciprofloxacin lactate content. In pH = 40 HAc NaAc buffer solution, ciprofloxacin lactate and sodium tetraphenylborate quantitatively formed a precipitate with a molecular ratio of 1: 1. After the precipitation reaction was completed, the filtrate was discarded and the filtrate was discarded. With bromophenol blue as an indicator, titration of excess sodium tetraphenylborate in the filtrate with cetyltrimethylammonium bromide standard solution was simple and rapid, and was applied to the determination of multiple ciprofloxacin lactate APIs , The recovery rate was 99 6 6% -10 2%, the relative error was less than ± 40%, which was basically the same as the Chinese Pharmacopoeia