在联合疫苗与多价疫苗研制过程中 ,抗原总量的增加可能是个问题 ,制备高效抗原可使疫苗的抗原含量减至最小。研究发现弱抗原性抗原经化学交联后能诱生抗体。为此作者在小鼠呼吸道感染模型中研究了化学交联抗原组成的无细胞百日咳疫苗的效力。　　作者将百日咳杆菌 Tohama株在改 In the development of combination vaccines and multivalent vaccines, an increase in the total amount of antigens can be a problem, and the preparation of high-efficiency antigens can minimize the antigenic content of the vaccine. The study found that weak antigen antigen chemically cross-linked antibodies can be induced. To do this, the authors investigated the efficacy of acellularly delivered pertussis vaccine consisting of chemically cross-linked antigens in a mouse model of respiratory infection. The author changes the pertussis tohama strain