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为探索柔毛霉素（ｄａｕｎｏｒｕｂｉｃｉｎ，ＤＮＲ）、骆驼蓬总碱（ｔｏｔａｌａｌｋａｌｏｉｄｏｆＨａｒｍａｌｉｎｅ，ＴＡＨ）对兔后发性白内障形成的影响及对兔眼的毒性作用。于兔晶体囊外摘除（ｅｘｔｒａｃａｐｓｕｌａｒｌｅｎｓｅｘｔｒａｃｔｉｏｎ）术中分别注入０．１ｍｌ的ＴＡＨ（０．２ｍｇ／ｍｌ）、ＤＮＲ（０．２ｍｇ／ｍｌ），观察兔晶体后囊混浊、眼内压的变化等；并观察术后组织病理学和超微结构的变化。结果显示：１５眼注入ＴＡＨ术后炎性反应与对照眼无明显差别；术后２周后囊膜明显比对照组清晰，术后４周有轻度混浊，但比对照眼轻。至术后８周仍有差别；１０眼注入ＤＮＲ后，表现出明显的炎性反应，角膜明显水肿且增厚，前房大量纤维素性渗出。组织病理学检查表明，对照眼术后晶体上皮细胞（ｌｅｎｓｅｐｉｔｈｅｌｉａｌｃｅｌｓ，ＬＥＣ）增生，并形成明显的ｓｏｅｍｍｅｔｉｎｇ环。ＴＡＨ引起晶体上皮细胞空泡变性、核固缩并能明显抑制兔眼的晶体上皮细胞增殖，且对角膜内皮及其它组织无明显毒性；而ＤＮＲ虽可明显抑制ＬＥＣ增生，但角膜基质层明显水肿并伴有大量的炎性细胞浸润，且角膜内皮细胞均很少见，表现了明显的眼部毒性。结论：ＴＡＨ能有效的抑制晶体上皮细?
To explore the effect of daunorubicin (DNR) and totalalkaloid of Hamaline (TAH) on the development of posterior capsate in rabbits and its toxicity to rabbit eyes. 0.1 ml of TAH (0.2 mg / ml) and DNR (0.2 mg / ml) were injected into extracapsular lense extracranial surgery respectively to observe the changes of posterior capsule opacities and intraocular pressure in rabbits. Postoperative histopathological and ultrastructural changes were observed. The results showed that there was no significant difference between the 15 eyes injected with TAH and the control eye. After 2 weeks, the capsule was obviously clearer than the control group, mild turbid 4 weeks after operation, but lighter than the control. After 8 weeks of operation, there was still a difference. In 10 eyes, DNR showed obvious inflammatory reaction, obvious edema and thickening of cornea, and extensive exudation of cellulose in anterior chamber. Histopathological examination showed that proliferative lens epithelial cells (LECs) proliferated after surgery and formed a distinct soemmeting ring. TAH induced cell vacuolar degeneration, nuclear pyknosis and significantly inhibited the proliferation of rabbit lens epithelial cells, and no obvious toxicity to the corneal endothelium and other tissues. While DNR could significantly inhibit LEC proliferation, corneal stromal edema Accompanied by a large number of inflammatory cell infiltration, and corneal endothelial cells are rare, showing significant ocular toxicity. Conclusion: TAH can effectively inhibit the fine epithelium?