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目的探讨安尔碘或过氧化氢溶液联合阿奇霉素治疗宫颈支原体感染的疗效。方法采用完全随机对照试验研究方法,将2004年6月至2005年7月清华大学玉泉医院妇科门诊宫颈分泌物支原体(Uu或Mh)培养阳性者随机分成3组,对照组为单纯应用阿奇霉素治疗组;观察Ⅰ组为安尔碘液联合阿奇霉素用药组;观察Ⅱ组为过氧化氢溶液联合阿奇霉素用药组。各组分别于治疗开始的第10天进行宫颈拭子支原体培养,阳性者间隔两周再次复查,根据培养结果,结合症状、体征判断疗效。结果观察Ⅰ组、观察Ⅱ组和对照组的临床有效率分别为93.3%、90.0%和50.0%,两观察组分别与对照组比较差异均有显著性意义(P<0.05)。两观察组之间比较差异无显著性意义(P>0.05)。结论安尔碘液或过氧化氢溶液与阿奇霉素联合用药均为治疗宫颈支原体感染的有效方法。
Objective To investigate the efficacy of arsenic iodide or hydrogen peroxide solution combined with azithromycin in the treatment of cervical mycoplasma infection. Methods A totally randomized controlled trial was conducted. The positive patients with cervical secretions mycoplasma (Uu or Mh) from Yuchao Hospital of Tsinghua University from June 2004 to July 2005 were randomly divided into three groups. The control group was treated with azithromycin alone ; Group Ⅰ was treated with azole and azithromycin; group Ⅱ was treated with hydrogen peroxide solution combined with azithromycin. Groups were treated on the 10th day of treatment of cervical swab mycoplasma culture positive again interval of two weeks to review again, according to the culture results, combined with symptoms and signs to determine the efficacy. Results The clinical effective rates in group Ⅰ and group Ⅱ were 93.3%, 90.0% and 50.0% respectively. There was significant difference between the two observation groups and the control group (P <0.05). There was no significant difference between the two observation groups (P> 0.05). Conclusions The combination of alanine solution or hydrogen peroxide solution with azithromycin is an effective method for the treatment of cervical mycoplasma infection.