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目的探讨131Ⅰ治疗Graves甲状腺功能亢进的疗效。方法将2009年10月～2010年7月期间我院收治的306例确诊为Graves甲状腺功能亢进患者按随机数字表法分为对照组与观察组,每组各含患者153例,对照组患者接受抗甲状腺药物治疗,观察组患者接受131I治疗,现对比分析两组患者的疗效以及不良反应发生率。结果①观察组治愈率、治疗有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。②两组患者突眼发生率、突眼缓解率相比差异无统计学意义(P>0.05)。③随访期内,观察组复发率显著低于对照组,甲亢性心脏病、肝功能受损、白细胞降低的发生率显著低于对照组,甲状腺功能减退发生率显著高于对照组,两组比较差异有统计学意义(P<0.05)。结论 131Ⅰ治疗Graves甲状腺功能亢进的疗效确切,具有治愈率、治疗有效率高,复发率低,不良反应发生率低等优点,但患者发生甲状腺功能减退的可能性增大,值得临床重视。
Objective To investigate the therapeutic effect of 131 Ⅰ on Graves hyperthyroidism. Methods 306 cases diagnosed as Graves’ hyperthyroidism in our hospital from October 2009 to July 2010 were divided into control group and observation group according to random number table. Each group contained 153 patients, and the control group received Anti-thyroid drug treatment, the observation group received 131I treatment, the efficacy of the two groups were compared and the incidence of adverse reactions. Results ① The cure rate and the treatment effective rate of the observation group were significantly higher than those of the control group, with significant difference between the two groups (P <0.05). ② There was no significant difference between the two groups in the rate of exophthalmos and the rate of exophthalmos (P> 0.05). ③The follow-up period, the observation group recurrence rate was significantly lower than the control group, hyperthyroidism heart disease, impaired liver function, the incidence of leukopenia was significantly lower than the control group, the incidence of hypothyroidism was significantly higher than the control group, the two groups compared The difference was statistically significant (P <0.05). Conclusion 131 Ⅰ treatment of Graves hyperthyroidism is effective, with cure rate, high treatment efficiency, low recurrence rate, low incidence of adverse reactions, but the possibility of patients with hypothyroidism increased, deserving clinical attention.