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目的探讨不同类型淋巴瘤患者血浆中肿瘤坏死因子-α(TNF-α)表达水平及其与不同临床特征和预后的关系。方法采用酶联免疫吸附(ELISA)法测定132例恶性淋巴瘤患者(病例组)及132例健康对照者(对照组)血浆中TNF-α的水平,分析TNF-α表达水平与IPI评分、有无全身症状和Ann Arbor分期的相关性。结果 (1)病例组TNF-α在霍奇金淋巴瘤(HL)、非霍奇金淋巴瘤(NHL)和弥漫大B细胞淋巴瘤(DLBCL)、小细胞淋巴瘤(SLL)表达水平高于对照组,差异无统计学意义(P>0.05)。在浆细胞瘤(PCN)和淋巴母细胞淋巴瘤(LBL)中TNF-α水平低于对照组,在LBL中TNF-α水平与对照组比较差异有统计学意义(P<0.05)。在HL和NHL血浆中TNF-α表达水平差异无统计学意义(P>0.05),而LBL与PCN、DLBCL、SLL组间差异有统计学意义(P<0.05)。(2)高危组淋巴瘤患者血浆TNF-α表达水平明显高于对照组和低危组,差异有统计学意义(P<0.05)。有全身症状组淋巴瘤患者血浆TNF-α表达水平明显高于对照组和无全身症状组,差异有统计学意义(P<0.05)。Ann ArborⅣ期淋巴瘤患者血浆TNF-α表达水平明显高于对照组及Ⅰ～Ⅲ期,差异有统计学意义(P<0.05)。结论 TNF-α的表达水平与IPI评分、有无全身症状和Ann Arbor分期有关,可作为淋巴瘤患者判断预后的辅助指标。
Objective To investigate the expression of tumor necrosis factor-α (TNF-α) in patients with different types of lymphoma and its relationship with different clinical features and prognosis. Methods The levels of TNF-α in plasma of 132 patients with malignant lymphoma (case group) and 132 healthy controls (control group) were measured by enzyme-linked immunosorbent assay (ELISA). The levels of TNF- No systemic symptoms associated with Ann Arbor staging. Results (1) The expression of TNF-α in cases of Hodgkin’s lymphoma (HL), non-Hodgkin’s lymphoma (NHL) and diffuse large B-cell lymphoma (DLBCL) and small cell lymphoma (SLL) The control group, the difference was not statistically significant (P> 0.05). The level of TNF-α in plasmacytoma (PCN) and lymphoblastic lymphoma (LBL) was lower than that in control group. The level of TNF-α in LBL was significantly lower than that in control group (P <0.05). There was no significant difference in the expression of TNF-α between HL and NHL plasma (P> 0.05), but there was significant difference between LBL and PCN, DLBCL and SLL (P <0.05). (2) The plasma levels of TNF-α in high-risk group were significantly higher than those in control group and low-risk group (P <0.05). Plasma TNF-αlevels in patients with systemic symptoms were significantly higher than those in control group and without systemic symptoms (P <0.05). The level of plasma TNF-αin patients with Ann Arbor stage Ⅳ lymphoma was significantly higher than that in control group and stage Ⅰ ~ Ⅲ (P <0.05). Conclusion The expression level of TNF-α is correlated with IPI score, systemic symptom and Ann Arbor staging. It can be used as an adjunct to prognosis in patients with lymphoma.