继发于重症感染的脓毒症可引起全身炎性反应和广泛的组织损伤,可导致多器官功能障碍,甚至多器官功能衰竭,如呼吸功能衰竭、肝肾功能衰竭等[1],脓毒症病人的病死率为40%～70%[2],其中感染性休克是重症感染病人最常见的死亡原因[3]。重症感染病人发生多脏器功能障碍和衰竭的机制是多因素参与的过程,其中全身氧输送和外周氧需求之间的失衡是导致全身组织缺氧和功能障碍的重要 Sepsis secondary to severe infections can cause systemic inflammatory reactions and extensive tissue damage that can lead to multiple organ dysfunction and even multiple organ failure, such as respiratory failure, liver and kidney failure [1], sepsis The case fatality rate is 40% ~ 70% [2], of which septic shock is the most common cause of death in critically ill patients [3]. The pathogenesis of multiple organ dysfunction and failure in critically ill patients is a multifactorial process in which the imbalance between systemic oxygen delivery and peripheral oxygen demand is an important cause of systemic hypoxia and dysfunction