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为探讨新疆汉族原发性高血压(EH)患者血清转化生子因子β1(TGF-β1)水平与血压及高血压之间的关系。在流行病学调查的基础上采用病例-对照研究方法,对新疆300名汉族(150名高血压患者,150名正常对照者)人群进行调查问卷,测量血压、身高、体重等相关指标,用双抗体夹心ELISA法检测两组的血清TGF-β1浓度。结果显示:1.新疆汉族人TGF-β1水平与舒张压成正相关(r=1.141,P<0.05)。2.EH组血清TGF-β1浓度(35.27±12.12ng/mL)与对照组(31.47±11.82 ng/mL)差异没有统计学意义,TGF-β1浓度与性别、年龄无关。3.超重、肥胖、腹部肥胖、高胆固醇、高血糖是新疆汉族人群的高血压危险因素。由此可知,TGF-β1浓度升高可能参与了汉族人EH的发病过程,血清TGF-β1浓度升高可以与其他环境因素(肥胖)发生交互作用,增加了个体患高血压的危险度。
To investigate the relationship between serum transforming growth factor β1 (TGF-β1) and blood pressure and hypertension in Han Han patients with essential hypertension (EH). Based on the epidemiological investigation, a case-control study was conducted to investigate the relationship between blood pressure, height, weight and other related factors in 300 Han Chinese population (150 hypertensive patients and 150 normal controls) Antibody sandwich ELISA was used to detect serum TGF-β1 concentration in both groups. The results showed that: 1.The level of TGF-β1 in Xinjiang Han people was positively correlated with diastolic blood pressure (r = 1.141, P <0.05). The serum TGF-β1 concentration of 35.27 ± 12.12ng / mL in EH group was not significantly different from that in control group (31.47 ± 11.82ng / mL). The concentration of TGF-β1 was not related to sex and age. 3. Overweight, obesity, abdominal obesity, high cholesterol, high blood sugar is a risk factor for hypertension in Han Chinese in Xinjiang. Thus, elevated TGF-β1 may be involved in the pathogenesis of EH in Han Chinese, serum TGF-β1 concentrations may interact with other environmental factors (obesity), increasing the risk of hypertension in individuals.