论文部分内容阅读
目的探讨老年子宫内膜癌患者RECK、TFF2、ERβ的表达及其对疾病的预后作用。方法收集40例老年子宫内膜癌患者的术后标本(癌症组)与20例正常子宫内膜组织标本(对照组),通过免疫组化检测RECK、TFF2、ERβ的蛋白表达。结果癌症组RECK、TFF2、ERβ的阳性表达率分别为42.5%、47.5%和40.0%,均显著低于对照组(75.0%、80.0%和80.0%)(P<0.05)癌症组组织中RECK、TFF2阳性表达与临床病理分期、组织学分级、淋巴结转移和肿瘤复发密切相关(P<0.05);ERβ的表达与组织学分级和淋巴结转移密切相关(P<0.05),而与临床分期及肿瘤复发无相关性。结论 RECK、TFF2和ERβ在老年子宫内膜癌患者中表达各异,与老年子宫内膜癌的发生、发展密切相关,RECK和TFF2对老年子宫内膜癌预后评估具有参考意义。
Objective To investigate the expression of RECK, TFF2 and ERβ in elderly patients with endometrial carcinoma and their prognostic effects on the disease. Methods 40 cases of elderly patients with endometrial cancer were collected from the postoperative specimens (cancer group) and 20 cases of normal endometrial tissues (control group), and the protein expression of RECK, TFF2 and ERβ was detected by immunohistochemistry. Results The positive rates of RECK, TFF2 and ERβ in cancer group were 42.5%, 47.5% and 40.0%, respectively, which were significantly lower than those in control group (75.0%, 80.0% and 80.0%, P <0.05) The positive expression of TFF2 was closely related to the clinicopathologic stage, histological grade, lymph node metastasis and tumor recurrence (P <0.05). The expression of ERβ was closely related to histological grade and lymph node metastasis (P <0.05), but not to clinical stage and tumor recurrence No correlation. Conclusion RECK, TFF2 and ERβ are expressed differently in elderly patients with endometrial cancer and are closely related to the occurrence and development of elderly endometrial cancer. RECK and TFF2 may be useful for the prognosis evaluation of elderly patients with endometrial cancer.