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目的探讨奥氮平与利培酮治疗痴呆精神行为症状的临床效果以及安全性。方法将我院2013年1月~2014年1月收治的70例患有痴呆精神行为症状的患者随机分成对照组和治疗组，对照组行利培酮进行治疗，治疗组行奥氮平进行治疗，比较两组患者的治疗效果。结果治疗后，治疗组总有效率为85.71%，对照组为91.43%，对比显示差异无统计学意义（>0.05)；与治疗前相比，两组患者治疗2、4、8w后的BEHAVE-AD评分均有明显改善，且差异显示具有统计学意义（0.05)；治疗组不良反应率为11.43%，明显低于对照组的31.43%，且差异显示具有统计学意义（ 0.05); compared with before treatment, the two groups of patients after treatment BEHAVE 2,4,8w -AD scores showed significant improvement, and show a statistically significant difference ( 0.05); adverse reaction rate was 11.43% in treatment group was significantly 31.43% lower than the control group, and the difference was statistically significant display ( <0.05). Conclusion Olanzapine and risperidone behavioral and psychological symptoms of dementia have some clinical effect, but Olanzapine security even more significant, can reduce the incidence of adverse events, help patients get better treatment, worthy of promotion.