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用免疫组化法检57例乳腺癌患者的Cath－D在乳腺癌组织中间质细胞和癌细胞的表达情况。结果表明：间质细胞Cath—D的表达强度高于癌细胞（P＜0.01）；Cath—D阳性表达与乳腺癌的淋巴结转移呈正相关（P＜0．005）与五年生存期呈负相关（P＜O．0O5）；在无淋巴结和小于4个转移的病例中，间质Cath—D阳性表达与五年生存期呈负相关（P＜0．005），而癌细胞的阳性与淋巴结转移情况和五年生存期的关系无统计学意义。本研究提示乳腺癌间质Cath—D表达能作为预测乳腺癌预后因素之一。对选择高危人群进行针对性治疗有意义。
Immunohistochemistry was used to examine the expression of Cath-D in 57 breast cancer patients. The results showed that the expression level of Cath-D in stromal cells was higher than that of cancer cells (P<0.01). The positive expression of Cath-D was positively correlated with lymph node metastasis in breast cancer (P<0.005) and negatively correlated with 5-year survival. (P<0.005); In cases with no lymph nodes and less than 4 metastases, Cath-D positive expression of the interstitium was negatively correlated with 5-year survival (P<0.005), whereas positive and lymph node cancer cells were found. The relationship between metastasis and five-year survival was not statistically significant. This study suggests that the expression of Cath-D in breast cancer can be used as a predictor of prognosis in breast cancer. Targeted treatment of selected high-risk groups makes sense.