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应用９９ｍＴｃ－ＭＩＢＩ直肠灌注进行门脉显像，根据心肌及肝区放射性计数测定核素心、肝比值Ｈ／Ｌ和门体分流指数ＳＩ作为门静脉循环参数与术中门静脉测压等指标作统计学处理。１２例正常对照组的ＨＩＬ为０．１４５±０．０４２，ＳＩ为０．１２４±０．０２９；１８例非肝硬化性肝胆疾病组的Ｈ／Ｌ为０．２０７±０．０７６，ＳＩ为０．１６９±０．０５（ｐ均＜０．０１）；４７例肝硬化组的Ｈ／Ｌ为０．７５１±０．３１３。ＳＩ为０．４２２±０．０７５（与对照组及非肝硬化性肝胆疾病组比较Ｐ均＜０．００１）；根据Ｃｈｉｌｄ－ｐｌｌｇｈ分级的Ａ、Ｂ、Ｃ三组间的差异亦有显著意义（Ｐ均＜０．０５）。Ｈ／Ｌ、ＳＩ与术中测压呈高度正相关（ｒ＝０．９５，Ｐ＜０．０１）。以Ｈ／Ｌ≥０．３０、ＳＩ≥０．２２为阳性，诊断肝硬化门脉高压的灵敏度为９６％、特异性为９０％、准确性为９４％。表明本方法可作为诊断肝硬化门脉高压的新方法。
99mTc-MIBI rectal perfusion was performed for portal imaging. The radionuclide counts were used to determine the radionuclide nucleus, liver ratio H / L and portosystemic shunt index SI as the parameters of portal vein circulation and portal vein manometry deal with. HIL in 12 normal controls was 0.145 ± 0.042 and SI was 0.124 ± 0.029; H / L in 18 non-cirrhotic hepatobiliary diseases was 0.207 ± 0.076, SI was 0.169 ± 0.05 (p <0.01). The H / L of 47 patients with cirrhosis was 0.751 ± 0.313. SI was 0.422 ± 0.075 (P <0.001 vs control group and non-cirrhotic hepatobiliary disease group). There was also a significant difference among the three groups according to Child-pllgh classification (P <0.05). H / L and SI were highly correlated with intraoperative manometry (r = 0.95, P <0.01). With H / L≥0.30, SI≥0.22 as positive, the sensitivity of diagnosing portal hypertension of cirrhosis was 96%, the specificity was 90% and the accuracy was 94%. This method can be used as a new method to diagnose portal hypertension in cirrhosis.