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分析肺癌组织ＭＤＲ１和ＧＳＴ－π基因的表达和临床意义。方法：运用ＲＴ－ＰＣＲ方法对５１例手术切除肺癌组织和相应的癌周正常肺组织进行ＭＤＲ１和ＧＳＴ－πｍＲＮＡ检测。结果：ＭＤＲ１ｍＲＮＡ在正常肺组织和肺癌组织中表达阳性率分别为１３．７％（７／５１）和４３．１％（２２／５１）；而ＧＳＴ－πｍＲＮＡ阳性率则分别为１９．６％（１０／５１）和５１．０％（２６／５１）．ＭＤＲ１或ＧＳＴＤ－πｍＲＮＡ表达与肿瘤病理类型。组织分化、ＴＮＭ分期等均无明显的相关性（Ｐ＞０．０５）。１９例（３７．３％）发生ＭＤＲ１和ＧＳＴ－πｍＲＮＡ共表达；２２例（４３．１１％）二者均无表达；７例（１３．７％）仅表达ＧＳＴ－πｍＲＮＡ：３例（５．９％）仪表达ＭＤＲ１ｍＲＮＡ。结论：肺组织细胞在恶变过程中ＭＤＲ１和ＧＳＴ－πｍＲＮＡ表达均有所增加，二者在肺癌先天性耐药机制中均占有重要的作用，而且二者在肺癌中的表达基本是一致的。
The expression and clinical significance of MDR1 and GST-π in lung cancer tissues were analyzed. METHODS: MDR1 and GST-π mRNA were detected in 51 lung cancer tissues and corresponding normal lung tissues by RT-PCR. Results: The positive rates of MDR1 mRNA in normal lung tissue and lung cancer tissues were 13.7% (7/51) and 43.1% (22/51) respectively, while the positive rate of GST-πmRNA was 19.6% ( 10/51) and 51.0% (26/51). MDR1 or GSTD-π mRNA expression and tumor pathological type. There was no significant correlation between tissue differentiation and TNM staging (P>0.05). 19 cases (37.3%) had MDR1 and GST-πmRNA co-expression; 22 cases (43.11%) had no expression; 7 cases (13.7%) only expressed GST-πmRNA: 3 cases (5. 9%) The apparatus expresses MDR1 mRNA. Conclusion: The expression of MDR1 and GST-π mRNA in the lung tissue increased during the malignant process. Both of them play an important role in the innate resistance mechanism of lung cancer, and their expression in lung cancer is basically the same.