论文部分内容阅读
目的研究吡罗美拉汀(Neu-P11)对急性高眼压兔眼内压的影响。方法采用特伦德伦伯卧位法建立急性高眼压模型兔。建模后将33只急性高眼压新西兰大白兔分为局部给药组和全身给药组,给予生理盐水,褪黑素(Mel)和不同剂量的Neu-P11处理,局部给药通过眼角膜滴注固定体积(10μL)药物进行给药,全身给药通过灌胃固定体积(1 m L)药物进行给药,给药后平位休息2 h,然后再次置于卧位45 min,平位每小时测量一次眼内压,连续监测6 h,重复实验一周。结果新西兰大白兔经Trendelenburg卧位诱导后,眼内压约升高为正常组的1.9倍。局部给药组经NeuP11和Mel治疗后眼内压明显降低(P<0.05),且Neu-P11低浓度治疗组比高浓度组效果更佳。全身给药组Neu-P11和Mel均可明显降低眼内压,且Neu-P11对眼压的影响存在剂量依赖性,Neu-P11浓度越高眼内压下降速度越快。结论 Neu-P11和褪黑素均具有降低急性高眼压兔眼内压的作用。
Objective To study the effect of piroxicam (Neu-P11) on intraocular pressure in rabbits with acute ocular hypertension. Methods Acute ocular hypertension model rabbits were established by Trendelenburg method. Thirty-three New Zealand white rabbits with acute ocular hypertension were divided into local administration group and systemic administration group. The rats were treated with normal saline, melatonin (Mel) and different doses of Neu-P11. The topical administration was through the cornea A fixed volume (10 [mu] L) of drug was administered instillation, administered systemically by intragastric administration of a fixed volume (1 m L) of drug and rested for 2 h after administration and then resumed for 45 min in the supine position Intraocular pressure was measured every hour, continuous monitoring 6 h, repeat the experiment a week. Results New Zealand white rabbits after Trendelenburg supine position, the intraocular pressure increased about 1.9 times the normal group. Intraocular pressure was significantly decreased (P <0.05) after NeuP11 and Mel treatment in the topical administration group, and better in the Neu-P11 low-concentration treatment group than in the high-concentration group. The systemic administration of Neu-P11 and Mel can significantly reduce the intraocular pressure, and Neu-P11 on the intraocular pressure in a dose-dependent manner, the higher the concentration of Neu-P11 intraocular pressure decline faster. Conclusions Both Neu-P11 and melatonin have the effect of lowering intraocular pressure in rabbits with acute ocular hypertension.