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目的探讨子宫颈癌患者手术治疗前放疗对血清血管内皮生长因子(VEGF)、鳞状细胞癌抗原(SCC-Ag)水平的影响。方法选择我院肿瘤科子宫颈癌患者65例,随机分为观察组(33例)和对照组(32例),对照组行单纯手术治疗,观察组在手术前进行放疗,对比分析两组患者治疗前后的血清VEGF、SCC-Ag变化及近期预后情况。结果观察组和对照组术后血清VEGF、SCC-Ag含量均较治疗前降低,差异有统计学意义(P<0.05或P<0.01),且观察组优于对照组(P<0.05);观察组近期生存率为90.91%,优于对照组的71.88%(P<0.05),但两组之间并发症发生率差异无统计学意义(P>0.05)。结论术前放疗可明显降低子宫颈癌患者血清VEGF、SCC-Ag水平,且预后较好。
Objective To investigate the effect of radiotherapy on the levels of serum vascular endothelial growth factor (VEGF) and squamous cell carcinoma antigen (SCC-Ag) before operation in patients with cervical cancer. Methods Sixty-five patients with cervical cancer from our department of oncology were randomly divided into observation group (33 cases) and control group (32 cases). The control group was treated with surgery alone. The observation group received radiotherapy before surgery. Changes of serum VEGF and SCC-Ag before and after treatment and prognosis. Results The serum levels of VEGF and SCC-Ag in the observation group and the control group were significantly lower than those before treatment (P <0.05 or P <0.01), and the observation group was better than the control group (P <0.05) The recent survival rate was 90.91%, which was better than 71.88% (P <0.05) of the control group, but there was no significant difference in the incidence of complications between the two groups (P> 0.05). Conclusion Preoperative radiotherapy can significantly reduce the serum levels of VEGF and SCC-Ag in patients with cervical cancer, and the prognosis is good.