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探讨慢性肝炎患者血清肝纤维化指标（ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ）的临床实用价值。对２５００例慢性肝炎患者，用放射免疫法进行血清ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ的检测，其中２３７例进行肝穿刺及肝脏病理组织学检查。结果显示２５００例轻、中、重度慢性肝炎患者的ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ指标均有明显差异（Ｐ＜０．０１）；４项肝纤维化指标水平与乙肝患者的肝脏炎症活动度分级、肝纤维化程度分期与病理组织学分度均存在显著相关（ｒ＝０．２５６－０．３９９）。血清肝纤维化指标对判断慢性肝炎的肝纤维化和肝硬化倾向具有临床实用意义。
To investigate the clinical value of serum liver fibrosis index (HA, PCⅢ, Ⅳ-C, LN) in patients with chronic hepatitis. Serum samples of HA, PCⅢ, Ⅳ-C and LN were detected by radioimmunoassay in 2500 patients with chronic hepatitis, and 237 of them were examined by liver biopsy and liver histopathology. The results showed that the indexes of HA, PCⅢ, Ⅳ-C and LN in 2500 patients with mild, moderate and severe chronic hepatitis were significantly different (P <0.01). The indexes of liver fibrosis and liver inflammation in 4 hepatitis B patients Grading, degree of liver fibrosis and histological grade were significantly correlated (r = 0.256-0.399). Serum fibrosis indicators to determine the tendency of chronic hepatitis liver fibrosis and cirrhosis of clinical practical significance.