非典型β-内酰胺类抗生素是70年代后期和80年代初期迅速发展起来的有广泛临床应用价值的抗生素。由于几十年来,各种抗生素在临床上广泛使用,致使许多致病菌对β-内酰胺类抗生素产生耐药,其耐药原因之一,细菌产生包括各种青霉素酶和头孢菌素酶,破坏对酶不稳定的β-内酰胺抗生素,使它们失去活性,造成临床治疗上的困 Atypical β-lactam antibiotics are rapidly developed in the late 1970s and early 80s with a wide range of clinical value of antibiotics. Due to the widespread use of various antibiotics in clinical practice over the past decades, many pathogenic bacteria have become resistant to β-lactam antibiotics. One of the reasons for its resistance is that bacteria produce various kinds of penicillinase and cephalosporin, Destruction of the enzyme unstable β-lactam antibiotics, so that they lose their activity, resulting in clinical treatment of sleepy