【摘 要】
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Dear Editor,Alteative splicing (AS) of pre-mRNA is an evolutionarily conserved mechanism to increase transcriptomic and proteomic complexity,and hence phenotypi
【机 构】
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Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE),Northeast Normal Universit
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Dear Editor,Alteative splicing (AS) of pre-mRNA is an evolutionarily conserved mechanism to increase transcriptomic and proteomic complexity,and hence phenotypic diversity,via the production of multiple mRNA isoforms from a single gene (Reddy et al.,2013).AS is regulated by various cis-acting regulatory elements and RNA-binding proteins (Reddy et al.,2013).The finding that a large proportion of pre-mRNA splicing is often cotranscriptional (Gelfman et al.,2013) suggests the involvement of epigenetic mechanisms in splicing regulation.Epigenetic modifications can affect chromatin structure and the elongation rate of RNA polymerase Ⅱ (Pol Ⅱ) (Luco et al.,2011),and hence can directly or indirectly recruit spliceosomal proteins (Luco et al.,2011;Maor et al.,2015;Yearim et al.,2015).
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