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本文对１６例慢性支气管炎病人的粘膜分泌性ＩｇＡ（ＳＩｇＡ）免疫、细胞免疫和体液免疫状态与２１例正常人进行了对照研究。结果显示：慢性支气管炎病人的唾液ＳＩｇＡ与总ＩｇＡ含量（ｐ＜０．０５，Ｐ＜０．０５）、外周血淋巴细胞ＰＷＭ刺激培养上清液中ＩｇＡ与ＩｇＭ含量（Ｐ＜０．００５，Ｐ＜０．００１）、血清ＩｇＧ与ＩｇＭ含量（Ｐ＜０．００１，Ｐ＜０．００５）以及外周血ＣＤ８￣＋与ＣＤ８￣＋Ｔ淋巴细胞数目（Ｐ＜０．０５，Ｐ＜０．０５）均较正常人明显降低，而患者鼻分泌液中ＳＩｓＡ、ＩｇＡ与总ＩｇＡ含量（Ｐ＜０．００１，Ｐ＜０．００５，Ｐ＜０．００１）、外周血ＩＬ－２Ｒ￣＋（活化）Ｔ细胞数目（Ｐ＜０．０５）均较正常人显著增加。表明慢性支气管炎病人从粘膜免疫到外周血细胞免疫与体液免疫状态的低下，但不排除由于慢性感染或潜在的炎症引起的某些免疫指征的反应性增强。
In this paper, mucosal secretory IgA (SIgA) immunization, cellular immunity and humoral immunity in 16 patients with chronic bronchitis were compared with 21 healthy controls. The results showed that the content of SIgA and total IgA in salivary fluid of patients with chronic bronchitis (p <0.05, P <0.05), the content of IgA and IgM in culture supernatant of peripheral blood lymphocytes stimulated by peripheral blood lymphocytes (P <0.005, (P <0.001, P <0.005) and the number of CD8 + and CD8 + T lymphocytes in peripheral blood (P <0.05, P <0.05) ) Were significantly lower than those in normal subjects, while the levels of SIsA, IgA and total IgA in nasal secretion (P <0.001, P <0.005, P <0.001) ) T cells (P <0.05) than the normal significantly increased. It indicates that patients with chronic bronchitis have mucosal immunity to peripheral blood cell immunity and low humoral status, but do not rule out the reactivity of some immune indications due to chronic infection or potential inflammation.