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目的:研究手足口病患儿的血清中血管内皮细胞生长因子(VEGF)的变化。方法:将重庆市红十字会医院手足口病患儿根据病情分成手足口病普通病例组和重症病例组,以同期住院的非手足口病患儿为对照组,检测血清VEGF水平。结果:手足口病患儿血清中VEGF水平高于非手足口病对照组;手足口病重症病例的血清VEGF水平高于普通病例组,两组比较差异有统计学意义(t=2.618,P<0.01)。结论:血清VEGF水平检测可作为评估手足口病患儿病情的重要指标之一。
Objective: To study the changes of serum vascular endothelial growth factor (VEGF) in children with hand-foot-mouth disease. Methods: Children with hand-foot-mouth disease in Chongqing Red Cross Hospital were divided into two groups: common case group and severe case group according to their condition. Serum VEGF levels were measured in children with non-hand-foot-mouth disease in the same period. Results: Serum levels of VEGF in HFMD children were higher than those in non-HFMD patients. Serum levels of VEGF in HFMD patients were higher than those in normal cases (both t = 2.618, P < 0.01). Conclusion: The detection of serum VEGF level can be used as an important index to evaluate the condition of children with hand-foot-mouth disease.