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目的探讨中老年人群血清尿酸水平与代谢综合征(MS)及其各组分的关系。方法采用横断面研究,对2007年49～80岁成都成华区711例人群进行调查,并测量身高、体重、血压、空腹血糖、三酰甘油、高密度脂蛋白、低密度脂蛋白、血清尿酸等指标,采用SPSS 16.0软件分析尿酸与MS及MS各组分之间的关系。结果在中老年人群中,MS的发生率为25.60%,高尿酸血症的发生率为21.24%。女性MS、腹型肥胖、高三酰甘油血症和低高密度脂蛋白胆固醇血症的发生率均明显高于男性。尿酸与腰围、收缩压、三酰甘油、舒张压、高密度脂蛋白水平的相关系数分别为0.311、0.140、0.118、0.106和0.147,均有统计学意义(P<0.05)。男、女性尿酸与腰围的相关系数分别为0.173和0.321,均有统计学意义(P<0.05)。男、女性尿酸与空腹血糖的相关系数分别为0.049和0.183,均有统计学意义(P<0.05)。结论血清尿酸水平与MS及其各组分关系密切,血清尿酸水平和MS及其各组分间的关系存在性别差异。
Objective To investigate the relationship between serum uric acid level and metabolic syndrome (MS) and its components in middle-aged and elderly people. Methods A cross-sectional study was conducted to investigate the prevalence of body mass, weight, blood pressure, fasting blood glucose, triglyceride, high density lipoprotein, low density lipoprotein, serum uric acid, etc. in a survey of 711 people aged 49 to 80 years in Chengdu, Indicators, the use of SPSS 16.0 software analysis of uric acid and MS and the relationship between MS components. Results In the middle-aged and elderly population, the incidence of MS was 25.60% and the incidence of hyperuricemia was 21.24%. The incidence of female MS, abdominal obesity, hypertriglyceridemia and low-density lipoprotein cholesterol were significantly higher than those of men. The correlation coefficients of uric acid, waist circumference, systolic blood pressure, triglyceride, diastolic blood pressure and high density lipoprotein were 0.311,0.140,0.118,0.106 and 0.147, respectively (all P <0.05). The correlation coefficient of uric acid and waist circumference between male and female was 0.173 and 0.321, respectively, with statistical significance (P <0.05). The correlation coefficients of uric acid and fasting blood glucose in male and female were 0.049 and 0.183, respectively, with statistical significance (P <0.05). Conclusions Serum uric acid levels are closely related to MS and its components. There is a gender difference in serum uric acid level and MS and its components.