卵巢癌是妇科三大恶性肿瘤之一,其发病率呈逐年上升趋势,病死率始终居妇科肿瘤首位。传统的细胞来源学说认为,上皮性卵巢癌来源于卵巢生发上皮,但是近年来卵巢癌新的分级方法即“二元论模型”以及新的细胞起源学说则彻底颠覆了传统的理论。本文就近年来卵巢癌发病机理的新观点做一综述。 Ovarian cancer is one of the three major gynecological malignant tumors, the incidence showed a rising trend year after year, the mortality rate always ranks first in gynecological tumors. According to the traditional theory of cell origin, epithelial ovarian cancer originated from the ovarian germinal epithelium, but in recent years, a new classification method of ovarian cancer, namely the “dualism model” and the new theory of cellular origin have completely overturned the traditional theory. This article reviews recent advances in the pathogenesis of ovarian cancer.