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目的:了解新药白蛋白结合型紫杉醇罕见的不良反应,提高用药的安全性。方法:报告1例应用白蛋白结合型紫杉醇后,出现致死性肺间质纤维化的晚期肺鳞癌患者的临床资料,进行分析讨论。结果:该例患者在应用白蛋白结合型紫杉醇10 d后出现发热、恶心呕吐、伴全身疼痛、乏力,23 d后出现咳嗽、咳痰、憋气,28 d出现严重的呼吸困难、窒息死亡。结论:白蛋白结合型紫杉醇可致肺间质纤维化,既往有肺间质病基础的患者应慎用,联合放疗时也可能加重放射性肺炎。
OBJECTIVE: To understand the rare side effects of new drug albumin-bound paclitaxel and to improve the safety of medication. Methods: One case of advanced lung squamous cell carcinoma with lethal pulmonary fibrosis after albumin-bound paclitaxel was reported and analyzed. Results: The patient developed fever, nausea and vomiting after 10 days of administration of albumin-bound paclitaxel, with generalized pain and weakness. After 23 days, he developed cough, expectoration and suffocation. He developed severe respiratory problems on day 28 and died of suffocation. CONCLUSIONS: Albumin-bound paclitaxel causes pulmonary interstitial fibrosis. Patients with previous evidence of interstitial lung disease should be used with caution. Radiation pneumonitis may also be aggravated when combined with radiotherapy.