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Podoplanin(平足蛋白)是淋巴内皮细胞的特异性标记,它还广泛表达于正常组织细胞及多种恶性肿瘤细胞。Podoplanin与肿瘤的侵袭及转移相关,但在不同肿瘤中,其表达情况不同,与肿瘤的临床病理特征及预后的相关性也不同。在头颈鳞癌中,Podoplanin高表达与口腔癌、口咽癌、舌癌淋巴结转移相关,与喉癌淋巴结转移无关;Podoplanin高表达与口腔癌预后差相关。尚无临床研究发现Podoplanin表达与头颈鳞癌复发或远处转移相关。
Podoplanin, a specific marker of lymphatic endothelial cells, is also widely expressed in normal tissue cells and various malignant cells. Podoplanin is related to tumor invasion and metastasis, but its expression is different in different tumors, which is different from the clinicopathological features and prognosis of tumors. In head and neck squamous cell carcinoma, Podoplanin overexpression is associated with lymph node metastasis of oral cancer, oropharyngeal cancer and tongue cancer, but not with lymph node metastasis of laryngeal cancer. Podoplanin overexpression is associated with poor prognosis of oral cancer. There is no clinical study found Podoplanin expression associated with recurrence or distant metastasis of head and neck squamous cell carcinoma.