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目的观察狗舌动脉一次性灌注氮芥对正常舌体组织的影响方法采用剂量为1mgml的抗癌药物氮芥1～2ml对狗舌动脉行一次性灌注于灌注后30min、1天、4天、8天切取狗注射侧舌体组织进行HE染色光镜观察结果光镜下见灌注药物后30min1、4、8天狗舌组织粘膜上皮细胞、结缔组织及肌纤维组织均未见明显变性、坏死等病理学改变结论舌动脉内一次性灌注化疗药物氮芥1.2mg1mgml不引起正常组织毒性刺激作用及损伤
Objective To observe the effect of one-time perfusion of nitrogen mustard on tongue tissue in tongue lingual artery using a dose of 1mgml of the anticancer drug mustard 1~2ml for a one-time perfusion of dog tongue artery perfusion 30min, 1 day, 4 days, After 8 days, the tongue tissues of the injection side of the dog were cut down and HE staining was performed. Light microscopy observations The pathological changes of mucosal epithelial cells, connective tissue, and myofibers of the tongue were not obvious at 30 min, 1, 4 and 8 days after the drug injection. Conclusions: One-time infusion of the chemotherapeutic drug nitrogen mustard 1.2mg 1mgml in the lingual artery does not cause normal tissue toxicity and injury.