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目的 :探讨嗜酸细胞阳离子蛋白 (ECP)在儿童哮喘发病中的作用。方法 :采用 Pharm acia U ni CAP系统检测 2 5例哮喘患儿急性发作期及 17例治疗后血清 ECP的含量 ,计数静脉血嗜酸粒细胞 ,测定肺通气功能 FEV1 。结果 :急性发作期哮喘血嗜酸粒细胞 (0 .2 75± 0 .2 6 3)× 10 9/ L 较正常升高 (0 .0 6 8± 0 .0 2 8)× 10 9/ L,P <0 .0 1;血清 ECP浓度 (16 .0 9± 13.6 8) μg/L 高于正常对照和治疗后 (3.78± 1.77) μg/ L;(4 .2 4± 2 .5 6 ) μg/ L,P <0 .0 1。哮喘患儿血嗜酸粒细胞计数与血 ECP浓度存在显著正相关 (r =0 .5 716 ,P <0 .0 1)。血清 ECP含量与 FEV1 呈显著负相关 (r =- 0 .430 9,P <0 .0 5 )。结论 :ECP在哮喘气道炎症机制中起作用 ,反映哮喘活动情况 ,是临床评价哮喘嗜酸细胞炎症的参考指标之一
Objective: To investigate the role of eosinophil cationic protein (ECP) in the pathogenesis of childhood asthma. Methods: Pharm acia U ni CAP system was used to detect the levels of serum ECP in 25 children with acute exacerbation of asthma and 17 after treatment. Venous blood eosinophils were counted and pulmonary ventilatory function FEV1 was measured. Results: The levels of blood eosinophils (0.27 ± 0.263) × 10 9 / L in asthma group were significantly higher than those in normal group (0.068 ± 0.028) × 10 9 / L , P <0.01; serum ECP concentration (16.90 ± 13.68) μg / L was higher than that of the normal control and 3.78 ± 1.77 μg / L after treatment (4.24 ± 2.56) μg / L, P <0.01. There was a significant positive correlation between blood eosinophil counts and blood ECP concentration in children with asthma (r = 0.5716, P <0.01). There was a significant negative correlation between serum ECP and FEV1 (r = - 0.309, P <0.05). Conclusion: ECP plays a role in airway inflammation in asthma and reflects the activity of asthma, which is one of the reference indexes for clinical evaluation of eosinophilic asthma