二氯卡宾是应用最为广泛的活性中间体,早期制备二氯卡宾的方法为氯仿与叔丁醇钾等强碱作用,条件苛刻。一直到1969年Makosza和Wawrzyniewicz的著名论文发表后,用强碱水溶液和相转移催化剂制取二氯卡宾被认为是最简捷的方法。另据文献报道,以聚氧乙烯类表面活性剂作催化剂进行固-液相反应制备二氯卡宾也可获得较理想的结果。但广泛的实 Dichlorocarbene is the most widely used active intermediate. The early preparation method of dichlorocarbene is the strong base such as chloroform and potassium tert-butoxide. Until the publication of the famous paper of Makosza and Wawrzyniewicz in 1969, the preparation of dichlorocarbene with strong aqueous base and phase transfer catalyst was considered as the simplest method. According to reports in the literature, the use of polyoxyethylene surfactant as a catalyst for solid-liquid phase preparation of dichlorocarbene can obtain better results. But a wide range of real