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目的:探讨胃肠道肿瘤患者腹内脂肪组织中脂联素mRNA的表达及其临床意义。方法:临床收集39例胃肠道肿瘤手术患者(其中转移组21例,未转移组18例)和20例非肿瘤正常对照组腹内脂肪;提取脂肪组织中总RNA,采用real-time PCR技术检测脂联素的表达水平。结果:胃肠道肿瘤组脂肪组织脂联素水平较对照组降低,差异有统计学意义(P<0.05),肿瘤转移组(3.85±1.41)较未转移组(4.90±1.06)脂联素表达水平降低,但差异无统计学意义(P>0.05)。结论:脂肪组织脂联素表达水平降低与胃肠道肿瘤发生相关,为肿瘤治疗的新途径提供理论依据。
Objective: To investigate the expression of adiponectin mRNA in intra-abdominal adipose tissue of patients with gastrointestinal cancer and its clinical significance. Methods: Totally 39 abdominal gastrointestinal cancer patients (21 in metastasis group, 18 in non-metastasis group) and 20 in non-tumor normal control group were collected for intra-abdominal fat collection. The total RNA in adipose tissue was extracted and analyzed by real-time PCR Detection of adiponectin expression levels. Results: Adiponectin levels in adipose tissue of the gastrointestinal cancer group were significantly lower than those in the control group (P <0.05), adiponectin expression was significantly higher in the tumor metastasis group (3.85 ± 1.41) than that in the non-metastasis group (4.90 ± 1.06) Level decreased, but the difference was not statistically significant (P> 0.05). Conclusion: The decreased expression of adiponectin in adipose tissue correlates with the occurrence of gastrointestinal cancer and provides a theoretical basis for a new approach to tumor therapy.