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目的:探讨孕中期母血产前筛查对胎儿染色体异常和神经管畸形的临床价值。方法:应用酶联免疫法检测孕中期孕妇血中AFP、HCG-b的浓度,结合孕周、年龄、体重等因素,通过计算机软件计算风险率,对高风险孕妇进行羊水细胞染色体核型分析和B超确诊。结果:2 050位孕妇中筛查出唐氏综合征高风险45例,占2.1%,确诊10例。18-三体综合征36例,占1.7%,确诊4例。神经管畸形筛查高危17例,占0.8%,确诊3例。结论:孕中期产前筛查结合产前诊断,是减少先天性缺陷患儿出生的有效方法。
Objective: To explore the clinical value of maternal blood screening in the second trimester on fetal chromosomal abnormalities and neural tube defects. Methods: Serum levels of AFP and HCG-b in pregnant women during the second trimester of pregnancy were detected by enzyme-linked immunosorbent assay (ELISA). The risk of pregnant women with high risk was analyzed by karyotype analysis of amniotic fluid cytology with the combination of gestational age, age, body weight and other factors. B-diagnosed. Results: Among 2050 pregnant women, 45 cases of Down’s syndrome were screened with high risk (2.1%) and 10 cases were confirmed. 18-trisomy syndrome in 36 cases, accounting for 1.7%, 4 cases diagnosed. 17 cases of high risk of neural tube defects screening, accounting for 0.8%, diagnosed in 3 cases. Conclusion: Prenatal screening combined with prenatal diagnosis during the second trimester is an effective method to reduce the birth of children with congenital defects.