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目的研究原发性血小板减少性紫癜(ITP)骨髓巨核细胞形态学改变。方法选择31例急性ITP患者为急性组,19例慢性ITP患者为慢性组,以14例健康人员为对照组,观察对比三组研究对象骨髓巨核细胞形态学特点。结果急性组、慢性组与对照组比较在巨核细胞总数、原巨核、幼巨核、颗粒型、产血小板型各阶段细胞平均数均存在差异有统计学意义(P<0.05);急性组原巨核、幼巨核高于慢性组。结论急性或慢性ITP均表现为巨核细胞增多,急性与慢性巨核细胞各阶段细胞分布、数量也有一定的差异。
Objective To study the morphological changes of bone marrow megakaryocytes in idiopathic thrombocytopenic purpura (ITP). Methods Thirty-one acute ITP patients were selected as acute group, 19 chronic ITP patients as chronic group and 14 healthy volunteers as control group. Morphological characteristics of bone marrow megakaryocytes were observed and compared among three groups. Results The average numbers of megakaryocyte, megakaryocyte, megakaryocyte, granulocyte and platelet-producing cells in acute group, chronic group and control group were all statistically significant (P <0.05) Juvenile megakaryocytes than the chronic group. Conclusions Both acute and chronic ITP showed megakaryocyte proliferation. The number and distribution of cells in acute and chronic megakaryocytes were also different.