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前列腺素(prostaglandin,PG)是人体重要的化学调质之一,已知PGE_2和PGF_(2α)在肺内具有重要的生理功能,由于肺是PG生成释放和灭活的主要场所,是人体中含PG很高的组织之一,因此PG及共代谢产物与肺部疾患的关系也日益受到重视。本文就目前肺泡膜上新发现的白三烯(Leu-kotrienes)和PGS对肺的功能特点作扼要的介绍。 一、肺内PG和白三烯的代谢及功能: 肺泡膜能释放出自由的花生四烯酸,经环氧化酶(cylooxgenase)作用,合成前列腺素(PGS)、前列环素(prostacyclin,PGI_2)和血栓恶烷A_2(Thromboxane A_2,TXA_2)。
Prostaglandin (PG) is one of the important chemical mediators of the human body. It is known that PGE 2 and PGF 2α have important physiological functions in the lung. Since lung is the main site for the release and inactivation of PG, Therefore, the relationship between PG and co-metabolites and lung diseases is also receiving more and more attention. In this paper, the lung function features of Leu-kotrienes and PGS, which are newly discovered in alveolar membrane, are briefly introduced. First, lung PG and leukotriene metabolism and function: alveolar membrane can release free arachidonic acid, the role of cyclooxygenase (cylooxgenase), synthesis of prostaglandins (PGS), prostacyclin (prostacyclin, PGI_2 ) And Thromboxane A_2 (TXA_2).