盐酸苯乙哌酯(benpiate hydrochloride)是一种中枢性解胆碱能药物,为检测其生殖毒性,用本院实验动物中心提供的AMS纯系小鼠(体重:♂35.7±s3.2g,♀34.5±2.9g),于孕期d6～15im盐酸苯乙哌酯,50(相当于1/5 LD_(50),人临床拟用量5 000倍),5和0.5 mg·kg~(-1).阳性对照组于孕期d9～11im环磷酰胺10mg·kg~(-1),溶剂对照组给予等体积注射用水. 盐酸苯乙哌酯50 mg·kg~(-1)组母鼠体重降低,胚胎吸收率增高40.4％,活胎率降低58％,胎鼠体重减轻(1.2±s0.2 g),与溶剂对照组(分别为8.8％,90.2％和1.4±0.1g)比较有非常显著差别(P<0.01).50和5 Benpiate hydrochloride is a central cholinergic drug. To test its reproductive toxicity, AMS mice (body weight: 35.7 ± s 3.2 g, ♀ 34.5 ± 2.9g). During the pregnancy, diphenoxylate hydrochloride 50 (equivalent to 1/5 LD_ (50)) and 5 000 mg · kg ~ (-1) were used during pregnancy. In the positive control group, cyclophosphamide 10 mg · kg -1 at d9 ~ 11 im during pregnancy was injected into the solvent control group at the same volume of water for injection. The body weight of the estrogen hydrochloride 50 mg · kg -1 group was decreased, Absorption rate increased 40.4%, live birth rate decreased 58%, fetal rat weight loss (1.2 ± s0.2 g), compared with the solvent control group (8.8%, 90.2% and 1.4 ± 0.1g respectively) there is a very significant difference P <0.01) .50 and 5