目的:优选地龙提取物的干燥方式。方法:采用真空减压干燥、微波干燥和真空冷冻干燥对地龙提取物进行干燥制粉,以蛋白质含量及纤溶酶活性为考察指标,得出最佳干燥方式。结果:真空冷冻干燥方式制备的地龙活性组分提取物中生物活性与原药材的活性无显著性差异。结论:真空冷冻干燥能够较好的保留地龙提取物中的活性组分。 Purpose: It is preferable to dry the dragon extract. Methods: Drying and powdering the earthworm extract were carried out by vacuum drying, microwave drying and vacuum freeze drying. The best drying method was obtained by taking the protein content and plasmin activity as indexes. Results: There was no significant difference in the bioactivity between the active ingredient extracted from the vacuum lozenge and the original medicinal material. Conclusion: Vacuum freeze-drying can better retain the active ingredient of earthworm extract.