本文报告了肾病综合征急性期12例血清硒值为0.358±0.127μmol/L,健康对照25例为0.742±0.329μmol/L,前者明显低于后者,经统计学处理差异性显著(P<0.01)。资料还表明血清硒与血浆蛋白、白蛋白降低呈正相关,与尿蛋白呈负相关。讨论了血清硒减少时,肾小球产生损伤的机理。硒减少时抗体形成不足,可能是肾病综合征容易感染和复发原因之一。 This paper reports 12 cases of acute nephrotic syndrome serum selenium 0.358 ± 0.127μmol / L, 25 cases of healthy controls was 0.742 ± 0.329μmol / L, the former was significantly lower than the latter, the statistical difference was significant (P < 0.01). Data also showed that serum selenium and plasma protein, albumin was positively correlated, and negatively correlated with urinary protein. Discussed the mechanism of injury of glomeruli when serum selenium decreased. Antibody formation is insufficient when selenium is reduced, which may be one of the reasons that nephrotic syndrome is easily infected and relapsed.