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目的:考察在避光条件下4℃、25℃、37℃8h内注射用头孢地嗪钠与奥硝唑氯化钠注射液的配伍稳定性。方法:采用高效液相色谱法测定配伍液在不同温度条件下放置8h内不同时间点含量的变化,并观察其外观变化及测定pH。结果:注射用头孢地嗪钠与奥硝唑氯化钠注射液配伍液在4℃8h、25℃4h、37℃2h内外观及pH无明显变化,含量变化在5%内。结论:注射用头孢地嗪钠与奥硝唑氯化钠注射液配伍后4℃8h、25℃4h、37℃2h内可使用。
OBJECTIVE: To investigate the compatibility of cefodizime sodium and ornidazole and sodium chloride injection for 8 h at 4 ℃, 25 ℃ and 37 ℃ under dark conditions. Methods: The content of compatibility liquid in different time within 8h was measured by high performance liquid chromatography (HPLC). The change of appearance and the determination of pH were observed. Results: The contents of cefodizime sodium injection and ornidazole sodium chloride injection did not change significantly in appearance and pH within 8 hours at 4 ℃, 4 hours at 25 ℃ and 2 hours at 37 ℃. Conclusion: cefodizime sodium injection and ornidazole sodium chloride injection compatibility 4 ℃ 8h, 25 ℃ 4h, 37 ℃ 2h can be used.