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目的 :分析组织激肽释放酶结合蛋白(kallistatin,KS)在冠心病患者血浆中水平的差异以及与Gensini评分的相关性,揭示血浆KS水平与冠状动脉病变严重程度的相关性。方法:选取151例行冠脉造影检查的患者作为研究对象,统计其临床数据及造影结果。(1)根据冠脉病变分支结果分成4组:正常对照组、单支病变组、双支病变组、三支病变组,应用ELISA法测定患者血浆中KS含量;(2)根据Gensini评分评估其冠脉病变程度,将患者分为4组:A组(0分)、B组(>0~≤20分)、C组(>20~≤40分)、D组(>40~艽160分),两两比较各组间患者血中KS含量的差异,并探究KS水平与Gensini评分间的相关性。结果 :(1)根据冠脉病变分支结果分的4组中,血浆KS量分别为:对照组(95.35±32.00)μg/m L、单支病变组(78.19±25.27)μg/m L、双支病变组(66.19±25.93)μg/m L、三支病变组(51.84±23.26)μg/m L,各组间均具有统计学差异(P<0.01),KS水平与冠脉病变支数呈负相关;(2)根据Gensini评分分的A、B、C、D 4组中,KS含量分别为(101.66±36.50)μg/m L、(77.73±25.13)μg/m L、(61.58±23.06)μg/m L、(53.80±23.92)μg/m L,KS含量在各组间的差异有统计学意义(P<0.01);(3)KS含量与Gensini评分存在统计学上有显著的相关性(r=-0.371,P<0.001)。结论:冠心病患者血浆KS含量明显低于正常人群,且KS含量与Gensini评分存在显著的相关性。提示KS可能作为一个潜在的血管保护因子参与动脉粥样硬化性心脏病的发生发展过程。
OBJECTIVE: To analyze the difference of plasma kallistatin (KS) levels in patients with coronary heart disease and its correlation with Gensini score, and to reveal the correlation between plasma KS level and the severity of coronary artery disease. Methods: 151 patients undergoing coronary angiography were selected as the research object, and their clinical data and imaging results were collected. (1) According to the results of coronary artery disease, the patients were divided into 4 groups: normal control group, single vessel lesion group, double vessel lesion group and triple vessel lesion group. The plasma KS levels were determined by ELISA. (2) According to Gensini score, The patients were divided into 4 groups: group A (0 points), group B (> 0 ~ <20 points), group C (> 20-40 points), group D ) Were used to compare the difference of KS levels between the two groups. The correlation between KS level and Gensini score was also explored. Results: (1) According to the result of coronary artery disease, the amount of plasma KS in the four groups were 95.35 ± 32.00 μg / m L, 78.19 ± 25.27 μg / m L in the single vessel disease group, (66.19 ± 25.93) μg / m L, and three lesions (51.84 ± 23.26) μg / m L, with statistical significance among all groups (P <0.01). The levels of KS and the number of coronary lesions were (2) According to Gensini score, the contents of KS were (101.66 ± 36.50) μg / m L, (77.73 ± 25.13) μg / m L, (61.58 ± 23.06) (53.80 ± 23.92) μg / m L, and the difference was statistically significant (P <0.01). (3) There was a statistically significant correlation between KS content and Gensini score (R = -0.371, P <0.001). Conclusion: The content of plasma KS in patients with coronary heart disease is significantly lower than that in normal people, and there is a significant correlation between KS content and Gensini score. Suggesting that KS may participate in the development of atherosclerotic heart disease as a potential vascular protective factor.