笔者对2例患有慢性皮肤粘膜念珠菌病(CMC)和原发性甲状腺功能减退的2个家庭的临床和免疫学特征进行了描述。A家庭有3名兄妹同时患有念珠菌病和甲低,还有4名成员仅有甲低。B家庭有4名成员患有念珠菌病,其中1例男孩还患有甲低。所有CMC患者均从婴儿期即患有口腔念珠菌病和甲癣。面部溢脂性皮炎、全身性毛囊炎及剥脱性眼睑炎是其主要表现。于幼儿期甲低变得明显。在A家庭患病的兄妹身上没有发现甲状腺抗体,但B家庭那名患有甲低的男孩,在诊断时即查出有抗甲状腺过氧化物酶的抗体。免疫学检查显示血清免疫球蛋白浓度、淋巴细胞分类和增殖反应上存在个体差异,但并未观察到相同的异常。疫苗反应是正 The authors describe the clinical and immunological characteristics of 2 families with chronic cutaneous mucocutaneous candidiasis (CMC) and primary hypothyroidism. A family has three brothers and sisters at the same time suffering from candidiasis and hypothyroidism, there are only four members of a hypothyroidism. Four members of the B family had candidiasis, and one of the boys also had hypothyroidism. All CMC patients suffer from oral candidiasis and onychomycosis from infancy. Facial seborrheic dermatitis, systemic folliculitis and exfoliative blepharitis is its main manifestation. A low in early childhood became obvious. Thyroid antibodies were not found in the siblings of the A family, but the boy in the B family who had a hypothyroidism detected an anti-thyroid peroxidase antibody at diagnosis. Immunological tests showed individual differences in serum immunoglobulin concentrations, lymphocyte sorting, and proliferative responses, but no abnormalities were observed. Vaccine response is positive