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目的比较伴代谢综合征(MS)高血压患者与单纯高血压患者的微量白蛋白尿(MAU)及高分子量脂联素(HMW-ADP)水平的差异,探讨MAU与HMW-ADP的相关性及二者与伴MS高血压的关系。方法68例原发性高血压患者,根据有无MS分为伴MS高血压组(33例)与单纯高血压组(35例)。采用放射免疫分析法测定尿白蛋白/肌酐比(ACR),双抗体夹心ELISA法测定血清HMW-ADP。结果同单纯高血压组相比,伴MS高血压患者的尿ACR增高,血清HMW-ADP降低(P<0.01);Pearson相关分析显示,血清HMW-ADP与尿ACR差异无统计学意义(P>0.05);多因素BinaryLogistic回归分析显示,空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、ACR及HMW-ADP与高血压患者MS的发生具有关联性(P<0.05或0.01)。结论MS加重高血压患者肾功能损害;尿ACR与血清HMW-ADP没有明显相关性;尿ACR增高及血清HMW-ADP降低可促进高血压患者MS的发生。
Objective To compare the differences of microalbuminuria (MAU) and high molecular weight adiponectin (HMW-ADP) between hypertensive patients with metabolic syndrome (MS) and those with simple hypertension and to explore the correlation between MAU and HMW-ADP The relationship between hypertension and MS. Methods Sixty-eight patients with essential hypertension were divided into MS group (n = 33) and hypertension group (n = 35) according to presence or absence of MS. Urinary albumin / creatinine ratio (ACR) was measured by radioimmunoassay and serum HMW-ADP was measured by double antibody sandwich ELISA. Results Compared with simple hypertensive group, urinary ACR increased and serum HMW-ADP decreased in MS patients with hypertension (P <0.01). Pearson correlation analysis showed no significant difference between serum HMW-ADP and urine ACR (P> 0.05). The multivariate Binary Logistic regression analysis showed that fasting blood glucose (FPG), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), ACR and HMW-ADP It was associated with the occurrence of MS in hypertensive patients (P <0.05 or 0.01). Conclusions MS aggravates renal dysfunction in patients with hypertension; urine ACR has no significant correlation with serum HMW-ADP; increased urine ACR and serum HMW-ADP can promote the occurrence of MS in hypertensive patients.