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本文比较了２３例ＭＤＳ和９例ＡＡ患者４种红细胞酶的活性，除醛缩酶（ＡＬＤ）外，丙酮酸激酶（ＰＫ）、嘌呤核苷磷酸化酶（ＰＮＰ）、腺苷脱氨酶（ＡＤＡ）在ＡＡ患者均接近正常，和ＭＤＳ差异显著，尤其是ＰＫ和ＰＮＰ差异显著。据此联合检测红细胞４种酶活性，建立了ＭＤＳ和ＡＡ的判别函数式：ＰＭＤＳ＝－５．０４１０７＋０．２５６７４ＰＫ＋１．６７６５１ＡＬＤ＋０．０３４８１ＰＮＰ＋０．２５０２４ＡＤＡ，ＰＡＡ＝－７．９００３８＋０．３８４６ＰＫ＋１．４９６２１ＡＬＤ＋０．０８０５ＰＮＰ＋０．１３２３７ＡＤＡ。内部回代结果，判别敏感度ＭＤＳ为８２．６１％，ＡＡ为７７．７８％，特异度ＭＤＳ可达９０．４８％，ＡＡ仅为６３．６４％。结果表明，该判别函数式可反映红系病态造血用于临床作为ＭＤＳ诊断的辅助指标。
In this study, we compared the activity of 4 erythrocytes from 23 patients with MDS and 9 patients with AA. In addition to aldolase (ALD), pyruvate kinase (PK), purine nucleoside phosphorylase (PNP), adenosine deaminase ADA) in AA patients were close to normal, and MDS significant difference, especially PK and PNP significant difference. According to the results, the discriminant functions of MDS and AA were established respectively. PMDS = -5.04107 + 0.25674PK + 1.67651ALD + 0.03481PNP + 0.25024ADA, PAA = -7.90038 + 0.3846PK + 1.49621ALD + 0.0805PNP + 0.13237ADA. Internal back-substitution results showed that the discriminant sensitivity was 82.61% for MDS, 77.78% for AA, 90.48% for MDS, and 63.64% for AA. The results show that the discriminant function can reflect the erythroid dysplasia used in clinical diagnosis as a secondary indicator of MDS.