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本文比较了23例MDS和9例AA患者4种红细胞酶的活性,除醛缩酶(ALD)外,丙酮酸激酶(PK)、嘌呤核苷磷酸化酶(PNP)、腺苷脱氨酶(ADA)在AA患者均接近正常,和MDS差异显著,尤其是PK和PNP差异显著。据此联合检测红细胞4种酶活性,建立了MDS和AA的判别函数式:PMDS=-5.04107+0.25674PK+1.67651ALD+0.03481PNP+0.25024ADA,PAA=-7.90038+0.3846PK+1.49621ALD+0.0805PNP+0.13237ADA。内部回代结果,判别敏感度MDS为82.61%,AA为77.78%,特异度MDS可达90.48%,AA仅为63.64%。结果表明,该判别函数式可反映红系病态造血用于临床作为MDS诊断的辅助指标。
In this study, we compared the activity of 4 erythrocytes from 23 patients with MDS and 9 patients with AA. In addition to aldolase (ALD), pyruvate kinase (PK), purine nucleoside phosphorylase (PNP), adenosine deaminase ADA) in AA patients were close to normal, and MDS significant difference, especially PK and PNP significant difference. According to the results, the discriminant functions of MDS and AA were established respectively. PMDS = -5.04107 + 0.25674PK + 1.67651ALD + 0.03481PNP + 0.25024ADA, PAA = -7.90038 + 0.3846PK + 1.49621ALD + 0.0805PNP + 0.13237ADA. Internal back-substitution results showed that the discriminant sensitivity was 82.61% for MDS, 77.78% for AA, 90.48% for MDS, and 63.64% for AA. The results show that the discriminant function can reflect the erythroid dysplasia used in clinical diagnosis as a secondary indicator of MDS.