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肝性脊髓病(HM)是由肝病引起的颈髓以下脊髓侧索脱髓鞘病变,临床表现为肢体缓慢进行性对称性痉挛性瘫痪。肝功能不全或肝功能异常是HM的主要原因。该病病理学表现为脊髓锥体束脱髓鞘,并有神经轴索的变性、消失及神经纤维的明显减少,代之以神经胶质填充。临床特征为严重肝病,或伴有反复发作的肝昏迷,脊髓受损后表现为双下肢痉挛性强直和腱反射亢进等。目前对HM尚无特效的预防和治疗方法,且预后不良。
Hepatic myelopathy (HM) is a myelinated demyelinating myelinated spinal cord below the spinal cord caused by liver disease, a clinical manifestation of a slow progressive symmetrical spastic paralysis of the limbs. Liver dysfunction or abnormal liver function is the main reason for HM. The pathological manifestations of demyelination of the spinal cord pyramidal tract and axonal degeneration, disappearance and significant reduction of nerve fibers, replaced by glial filling. Clinical features of severe liver disease, or recurrent hepatic coma, spinal cord injury manifested as double lower extremity spastic tonic and tendon hyperreflexia. At present there is no effective prevention and treatment of HM, and the prognosis is poor.