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目的探讨淋巴结阳性乳腺癌患者手术前后动脉辅助化疗的疗效及安全性。方法68例术后淋巴结病理学检查阳性的乳腺癌患者,采用股动脉穿刺插管,分别经锁骨下动脉和内乳动脉灌注氟尿嘧啶800mg、吡喃阿霉素40mg、环鳞酰胺800mg各一半,手术前2次,手术后3次。记录患者平均住院日、费用、副反应及并发症,随访患者5年总生存率(OS)和无病生存率(DFS),并与同期全身静脉化疗的70例对比。结果动脉插管化疗后患者平均住院日为7d,副反应及并发症明显少于静脉化疗组,5次总费用为18 615元,与静脉组相当;5年生存率为100%,无病生存率为91.03%,明显高于静脉组。结论乳腺癌手术前后采用经导管动脉辅助化疗,患者住院时间短、恢复快、不良反应少、疗效指数明显高于静脉化疗,是一种有效的辅助化疗途径。
Objective To investigate the efficacy and safety of arterial adjuvant chemotherapy in patients with lymph node-positive breast cancer before and after operation. Methods Sixty-eight patients with positive postoperative pathological examination of lymph nodes were treated with femoral artery puncture and intubation. Fluorouracil 800 mg, pirarubicin 40 mg and cyclosporine 800 mg were respectively infused via the subclavian artery and internal mammary artery. 2 times before, 3 times after surgery. The average hospitalization days, costs, side effects and complications were recorded. The 5-year overall survival (OS) and disease-free survival (DFS) were followed up and compared with 70 cases of systemic vein chemotherapy during the same period. Results The average length of stay after arterial intubation chemotherapy was 7 days. The side effects and complications were significantly less than those in the intravenous chemotherapy group. The total cost for 5 sessions was 18,615 yuan, equivalent to that of the vein group. The 5-year survival rate was 100% and disease-free survival Rate was 91.03%, significantly higher than the vein group. Conclusion The transcatheter arterial adjuvant chemotherapy before and after breast cancer surgery, patients with short hospital stay, rapid recovery, fewer adverse reactions, efficacy index was significantly higher than intravenous chemotherapy, is an effective adjuvant chemotherapy.