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目的通过幼鼠重复吸入氯氟醚菊酯蚊香28 d的亚急性毒性研究了解该蚊香对幼鼠可能存在的毒性。方法对SD雌雄刚断乳大鼠静式染毒28 d,进行血液学、血清生化学及组织病理学检查和脏器系数等指标的测定。结果雄鼠中高剂量组ALT指标明显高于对照组;雄鼠3个剂量组肝脏器系数高于对照组;雌鼠高剂量组肝脏湿重明显高于对照组,且上述差异均有统计学意义(P<0.05);雌雄高剂量组动物肝细胞不同程度胞质疏松,空泡状,部分肝细胞肿胀,噬碱性小体减少,肝索排列紊乱等;雄鼠中高剂量组及雌鼠中剂量组CHO指标明显高于对照组,差异均有统计学意义(P<0.05)。结论氯氟醚菊酯蚊香主要作用的靶器官是肝脏,具有一定的肝脏毒性。
OBJECTIVE: To study the subacute toxicity of fenvalerate inhalation for 28 days in young rats to find out the possible toxicities of the mosquito coils to young rats. Methods The SD male and female weaned rats were exposed to static radiation for 28 days. The hematology, serum biochemistry, histopathology and organ coefficient were measured. Results The ALT index of high-dose and middle-dose male rats was significantly higher than that of the control group. The liver coefficient of the three dose groups was higher than that of the control group. The high-dose female rats’ liver wet weight was significantly higher than that of the control group (P <0.05). In the male and female high-dose group, the degree of hepatocyte in the high-dose group was different from that of the normal group (cytoplasmic, vesicular, hepatocyte swelling, The CHO index of the dose group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion The main target organ of mosquito-repellent mosquito is liver, which has some hepatotoxicity.