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目的 观察和分析小剂量氟脲嘧啶 (5 -FU)与小剂量顺铂 (PDD)联合治疗晚期胃肠道癌的临床疗效和毒副反应。方法 35例中胃癌 2 2例 ,肠癌 13例。 5 -FU 2 0 0mg/m2 每天 ,持续静滴 3～ 4周 ;PDD 6mg/m2 每天 ,静滴 2小时 ,每周 5天 ,连用 3～ 4周。结果 无CR病例 ,PR17例 ,总有效率为 48 6 %。胃癌有效率为 5 4 6 % ,肠癌有效率为 38 5 % ,用过含 5 -FU方案治疗的患者有效率为43 8%。主要毒性反应为口腔炎、腹泻、恶心、呕吐。骨髓抑制轻 ,多为Ⅰ°～Ⅱ°。绝大多数患者能耐受该方案治疗。结论 作者认为该方案疗效好 ,毒副反应轻 ,治疗费用少 ,便于开展 ,值得临床推广、研究
Objective To observe and analyze the clinical efficacy and side effects of low-dose fluorouracil (5 -FU) and low-dose cisplatin (PDD) in the treatment of advanced gastrointestinal cancer. Methods 35 cases of gastric cancer in 22 cases, 13 cases of intestinal cancer. 5 -FU 200 mg / m2 daily for 3 to 4 weeks; PDD 6 mg / m2 daily for 2 hours, 5 days a week for 3 to 4 weeks. Results no CR cases, PR 17 cases, the total effective rate was 48 6%. The effective rate of gastric cancer was 54.6% and that of colorectal cancer was 38.5%. The effective rate of patients treated with 5-FU-containing regimen was 43.8%. The main toxic reactions are stomatitis, diarrhea, nausea and vomiting. Myelosuppression light, mostly Ⅰ ° ~ Ⅱ °. The vast majority of patients can tolerate the program treatment. Conclusion The authors believe that the efficacy of the program, light side effects, treatment costs less, easy to carry, worthy of clinical promotion, research