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目的：对妊高征（ Ｐ Ｉ Ｈ） 患者进行抗心磷脂抗体（ Ａ Ｃ Ａ） 和抗 Ｄ Ｎ Ａ 抗体的检测，以探讨 Ｐ Ｉ Ｈ 与自身抗体间的关系。方法：采用 Ｅ Ｌ Ｉ Ｓ Ａ 方法对３０ 例 Ｐ Ｉ Ｈ 患者进行 Ａ Ｃ Ａ － Ｉｇ Ｇ、 Ａ Ｃ Ａ － Ｉｇ Ｍ 、 Ａ Ｃ Ａ Ｉｇ Ａ 、抗ｄｓ Ｄ Ｎ Ａ 、抗ｓｓ － Ｄ Ｎ Ａ 抗体测定。结果： Ｐ Ｉ Ｈ患者中 Ａ Ｃ Ａ 的阳性率为６３ ．３ ％ （１９／３０） ，正常妊娠妇女为６ ．６７ ％ （２／３０） ，其差异有高度显著性（ Ｐ ＜ ０ ．０１） 。 Ｐ Ｉ Ｈ 患者 Ａ Ｃ Ａ的免疫球蛋白类型中，以 Ｉｇ Ｇ 型 Ａ Ｃ Ａ 最为常见， Ｉｇ Ｍ 型或 Ｉｇ Ａ 型 Ａ Ｃ Ａ 阳性常伴随有 Ｉｇ Ｇ 型 Ａ Ｃ Ａ 阳性。妊高征组抗ｄｓ Ｄ Ｎ Ａ阳性率明显高于对照组（ Ｐ ＜ ０ ．０１） 。两组抗ｓｓ － Ｄ Ｎ Ａ 的阳性率无显著意义。结论： Ａ Ｃ Ａ 阳性，尤其是 Ａ Ｃ Ａ － Ｉｇ Ｇ 阳性与妊高征发病有密切关系。因此， 应对孕妇进行 Ａ Ｃ Ａ 检测，可作为能否正常妊娠的前瞻性指标。
OBJECTIVE: To detect anticardiolipin antibodies (A C A) and anti-D N A antibodies in patients with pregnancy-induced hypertension (PIH) to explore the relationship between P I H and autoantibodies. Methods: A total of 30 patients with PH were enrolled in this study. A C A - Ig G, A C A - Ig M, A C A - Ig A, anti - ds D N A, anti - ss N D A antibody assay. Results: The positive rate of A C A in P I H patients was 63. 3% (19/30), normal pregnant women 6. 67% (2/30), the difference was highly significant (P <0 .01). IgA-type A C A is the most common immunoglobulin type in PAH patients, and IgC-type or IgA-type A-C-positive is often accompanied by IgG-type A-C-A positive. The positive rate of anti-ds D N A in PIH group was significantly higher than that in control group (P <0.01). The positive rate of anti - ss - D N A in both groups was not significant. Conclusion: A C A positive, especially A C A - Ig G positive, is closely related to the pathogenesis of PIH. Therefore, pregnant women should be A C A test, can be used as a prospective pregnancy index.