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采用单克隆抗体、间接致敏红细胞花环试验法对复发性口疮（Ｒｅｃｕｒｒｅｎｔａｐｈｔｈｏｕｓ ｕｌｃｅｒ，ＲＡＵ）、胃癌及系统性红斑狼疮（Ｓｙｓｔｅｍ ｉｃ ｌｕｐｕｓ ｅｒｙｔｈｅｍ ａｔｏｓｕｓ，ＳＬＥ）患者外周血ＷｕＴ３、ＷｕＴ４、ＷｕＴ８ 及Ｔ４／Ｔ８ 比值进行检测。结果：胃癌患者ＷｕＴ３、ＷｕＴ４ 低于对照组（ Ｐ＜ ０．０５），ＷｕＴ８ 高于对照组，Ｔ４／Ｔ８ 比值明显低于对照组（ Ｐ＜ ０．００１）。ＳＬＥ组患者ＷｕＴ８ 较对照组低下，Ｔ４／Ｔ８ 比值增高（ Ｐ＜ ０．０５）。ＲＡＵ组患者ＷｕＴ３ 低于对照组，ＷｕＴ８ 高于对照组，Ｔ４／Ｔ８ 比值下降（ Ｐ＜ ０．０５）。认为：①胃癌的发生是机体总的细胞免疫处于低下无能状态，不能对肿瘤进行正常的免疫监视及免疫应答。②ＳＬＥ的发病与ＷｕＴ８ 功能降低有关，其导致自身反应细胞发生脱抑制而功能亢进。③ＲＡＵ 的发生是因ＷｕＴ８ 细胞功能增强，致使Ｔｃ细胞的作用增强，其直接攻击粘膜靶细胞造成粘膜坏死、溃疡
WuT3, WuT8 and T4 / T8 in peripheral blood of patients with recurrent aphthous ulcer (RAU), gastric cancer and systemic icupu erythem atosus (SLE) were detected by monoclonal antibody and indirect sensitized erythrocyte rosette. Ratio test. Results: The expressions of WuT3 and WuT4 in gastric cancer were lower than those in control group (P <0.05). WuT8 was higher than that in control group, and T4 / T8 ratio was significantly lower than that in control group (P <0.001). WuT8 in SLE group was lower than that in control group, and the ratio of T4 / T8 was increased (P <0.05). WuT3 in RAU group was lower than that in control group, WuT8 was higher than that in control group, and the ratio of T4 / T8 was decreased (P <0.05). That: ① the occurrence of gastric cancer is the body's total cellular immunity in the state of impotence, can not be normal tumor immune surveillance and immune response. ② The pathogenesis of SLE is related to the decrease of WuT8 function, which leads to derepression and hyperfunction of self-responding cells. The occurrence of RAU is due to the enhanced function of WuT8 cells, resulting in the enhanced role of Tc cells, which directly attack mucosal target cells resulting in mucosal necrosis, ulcers